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What do systematic reviews say?

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Evidence found and GRADE certainty

2 questions · 2 findings · 1 reviews · Epilepsy

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Pregabalin vs active comparators

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

Pregabalin probably leads to lower 50% or greater reduction in seizure frequency ‐ worst‐case analysis compared with active comparators (moderate certainty).

1 finding from 1 review

Pregabalin vs placebo

50% or greater reduction in seizure frequency · people with drug‐resistant focal epilepsy

It is very uncertain whether pregabalin changes 50% or greater reduction in seizure frequency ‐ worst‐case analysis compared with placebo (very low certainty).

1 finding from 1 review