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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews · Musculoskeletal

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No studies found 0 · 0%GRADE not reported 4 · 57.1%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Zoledronate vs pamidronate or risedronate

Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone

Zoledronate showed no clear difference in number of participants who experienced side effects related to use… compared with pamidronate or risedronate (low certainty).

1 finding from 1 review

Zoledronate vs pamidronate or risedronate

Number of participants with change in bone pain¹ assessed on VAS. · Paget's disease of bone

It is very uncertain whether zoledronate changes number of participants with change in bone pain¹ assessed on VAS. compared with pamidronate or risedronate (very low certainty).

1 finding from 1 review