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What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 22 findings · 3 reviews · Wounds

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No studies found 13 · 59.1%GRADE not reported 1 · 4.5%Very low 7 · 31.8%Low 1 · 4.5%Moderate 0 · 0%High 0 · 0%

Zinc oxide mesh vs placebo mesh

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

3 findings from 1 review

220 mg zinc sulphate supplement containing 50 mg elemental zinc vs placebo

Ulcer healing · people with diabetes and foot ulcers

It is very uncertain whether 220 mg zinc sulphate supplement containing 50 mg elemental zinc changes ulcer healing (absolute change in individual parameters of ulcer… compared with placebo (very low certainty).

4 findings from 1 review
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Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

The proportion of pressure ulcers healed · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes pressure ulcers healed compared with standard diet or placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Time to complete healing of pressure ulcers ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Acceptability of nutritional supplements ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

It is very uncertain whether summary of findings table ‐ Protein, arginine, zinc and antioxidants changes side effects: at least one adverse gastrointestinal event compared with standard diet or placebo (very low certainty).

1 finding from 1 review