Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

220 questions · 226 findings · 32 reviews

No studies found 70 · 31%GRADE not reported 51 · 22.6%Very low 39 · 17.3%Low 30 · 13.3%Moderate 29 · 12.8%High 7 · 3.1%

Zinc vs placebo

BMD Z score (lumbar spine) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (lumbar spine) compared with placebo (moderate certainty).

1 finding from 1 review

Zinc polycarboxylate cement vs Any other orthodontic band adhesive

Outcome not reported · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…

The review found no eligible studies for this question.

1 finding from 1 review

Zinc silicophosphate cement vs Any other orthodontic band adhesive

Outcome not reported · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…

The review found no eligible studies for this question.

1 finding from 1 review

Zinc oxide and eugenol (ZOE) vs ZOE + calcium hydroxide + iodoform (MPRCF, unnamed product)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Zinc oxide and eugenol (ZOE) led to lower clinical failure compared with ZOE + calcium hydroxide + iodoform (unnamed product); GRADE not reported.

1 finding from 1 review

Zinc oxide and eugenol (ZOE) vs RC Fill

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

The review found no eligible studies for this question.

1 finding from 1 review

Dual zinc + arginine dentifrice vs Control (regular fluoride) dentifrice

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether dual zinc + arginine dentifrice changes dentist-reported OLT hedonic rating (scale 1 to 9) compared with control (regular fluoride) dentifrice (very low certainty).

1 finding from 1 review

Chlorine dioxide + zinc mouthwash vs Placebo mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether chlorine dioxide + zinc mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo mouthwash (very low certainty).

1 finding from 1 review

Chlorine dioxide + zinc mouthwash vs Placebo mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Chlorine dioxide + zinc mouthwash led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

1 finding from 1 review