Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

220 questions · 226 findings · 32 reviews

No studies found 70 · 31%GRADE not reported 51 · 22.6%Very low 39 · 17.3%Low 30 · 13.3%Moderate 29 · 12.8%High 7 · 3.1%

Zinc vs placebo

Adverse events · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)

It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Zinc vs placebo

Taste acuity improvement - objective outcome (dichotomous data) · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)

It is very uncertain whether zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… changes taste acuity improvement - objective outcome (dichotomous data) compared with placebo (very low certainty).

1 finding from 1 review

Zinc chloride without sodium chlorite mouthrinse (Breath Rx containing cetylpyridinium chloride) vs Control mouthrinse (containing neither zinc chloride nor sodium chlorite)

Volatile sulphur compounds (VSC), halimeter · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    4 weeks
    Codipilly 2004: reported VSC reduction from baseline for zinc chloride minus sodium chlorite (Breath Rx containing cetylpyridinium chloride): 38% (P < 0.05) at 2 weeks, versus a control containing neither zinc chloride…
    1 study
    GRADE not reported

Zinc oxide mesh vs placebo mesh

Proportion of wounds healed · adults with open wounds after surgery for sacrococcygeal pilonidal sinus disease

The review found no eligible studies for this question.

3 findings from 1 review

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review

Zinc vs placebo

BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass

Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).

1 finding from 1 review