Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

78 questions · 82 findings · 10 reviews · Headline outcomes only

No studies found 15 · 18.3%GRADE not reported 0 · 0%Very low 16 · 19.5%Low 26 · 31.7%Moderate 14 · 17.1%High 11 · 13.4%

Neonatal vitamin A supplementation vs control

Vitamin A deficiency · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in vitamin A deficiency (serum retinol < 0.70 micromol/L) at 6 weeks of… compared with control (high certainty).

2 findings from 1 review

Vitamin A vs placebo or usual care

Diarrhoea incidence Mean episodes per child per year · children aged between 6 months and 5 years

Vitamin A supplementation may leads to lower diarrhoea incidence Mean episodes per child per year compared with placebo or usual care (low certainty).

1 finding from 1 review

Vitamin A vs placebo or usual care

Measles incidence Mean episodes of measles per child per year · children aged between 6 months and 5 years

Vitamin A supplementation probably leads to lower measles incidence Mean episodes of measles per child per year compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

All‐cause infant mortality at 6 months: risk ratios based on cumulative risk (%, adjusted for clustering) ‐ term infants · mortality and morbidity in term neonates

It is very uncertain whether neonatal vitamin A supplementation changes all‐cause infant mortality at 6 months: risk ratios based on… compared with control (very low certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Infant Mortality at 6 Months · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in all‐cause infant mortality at 6 months: risk ratios based on… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Neonatal mortality · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in all‐cause neonatal mortality: risk ratios based on cumulative risk… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Adverse events during first 48‐72 hours post supplementation ‐ bulging fontanelle · mortality and morbidity in term neonates

Neonatal vitamin A supplementation leads to higher adverse events during first 48‐72 hours post supplementation ‐… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Vomiting · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (high certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Adverse effects: diarrhoea 48 to 72 hours · mortality and morbidity in term neonates

Neonatal vitamin A supplementation showed no clear difference in adverse events during first 48‐72 hours post supplementation ‐… compared with control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal vitamin B12 deficiency · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review