Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 1 · 14.3%High 5 · 71.4%

Vitamin D plus calcium vs placebo or control

Persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in persons with hypercalcaemia ‐ Vitamin D (D2, D3 or 25(OH)D) plus… compared with control or placebo (low certainty).

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
RR 3.29 [0.37, 29.14]
2 studies · 3853 participants
Low

Vitamin D plus calcium vs placebo or control

Persons with renal disease (calculi or insufficiency) ‐ Vitamin D (D2, D3 or 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to higher persons with renal disease (calculi or insufficiency) ‐ Vitamin D… compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
RR 1.17 [1.03, 1.34]
2 studies · 39552 participants
High

Vitamin D plus calcium vs placebo or control

Deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium showed no clear difference in deaths ‐ Vitamin D (D2, D3, 25(OH)D) plus calcium (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
RR 0.94 [0.87, 1.02]
6 studies · 46794 participants
High

Vitamin D plus calcium vs placebo or control

Hip Fracture · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining new hip fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
RR 0.84 [0.74, 0.96]
9 studies · 49853 participants
High

Vitamin D plus calcium vs placebo or control

Persons sustaining new non‐vertebral fracture (1 year estimate) · post‐menopausal women and older people at risk of osteoporotic fractures

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
0.86 [0.78, 0.96]
8 studies · 10380 participants
High

Vitamin D plus calcium vs placebo or control

Fractures: vertebral or deformity · post‐menopausal women and older people at risk of osteoporotic fractures

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
0.89 [0.74, 1.09]
4 studies · 42185 participants
Moderate

Vitamin D plus calcium vs placebo or control

New fractures · post‐menopausal women and older people at risk of osteoporotic fractures

Vitamin D [D2, D3 or 25(OH)D] plus calcium leads to lower persons sustaining any new fracture (1 year estimate) compared with control or placebo (high certainty).

1 finding from 1 review

Vitamin D and vitamin D analogues for preventing fractures in post‐menopausal women and older men 2014 · Cochrane Headline outcomes only
RR 0.95 [0.9, 0.99]
10 studies · 49976 participants
High