What do systematic reviews say?

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in bleeding complications: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 0.12 [0.01, 2.11]
  1 study · 54 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 0.36 [0.04, 3.24]
  1 study · 54 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 1.36 [0.24, 7.57]
  1 study · 61 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 0.96 [0.06, 14.6]
  1 study · 53 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in necrotizing enterocolitis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 1.08 [0.16, 7.1]
  1 study · 54 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in sepsis: 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 0.86 [0.26, 2.86]
  1 study · 54 participants
  Low

Higher dose vitamin K vs lower dose vitamin K

Higher dose vitamin K showed no clear difference in mortality (all infants): 0.2 mg IM versus 0.5 mg IM compared with lower dose vitamin K (low certainty).

• Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
  RR 2.13 [0.6, 7.51]
  1 study · 65 participants
  Low

Vitamin D (higher dose) vs vitamin D (lower dose)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin D (higher dose) vs vitamin D (lower dose)

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  RR 1.16 [1, 1.35]
  6 studies · 554 participants
  Low

Vitamin D (higher dose) vs vitamin D (lower dose)

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  RR 1.39 [0.89, 2.18]
  5 studies · 986 participants
  Low

Vitamin D (higher dose) vs vitamin D (lower dose)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin D (higher dose) vs vitamin D (lower dose)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin D (higher dose) vs vitamin D (lower dose)

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 283 participants
  Very low

Vitamin D (higher dose) vs vitamin D (lower dose)

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 105 participants
  Low

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Low

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame: 3… compared with vitamin D (lower dose) + micronutrient(s) (low certainty).

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  RR 1 [0.06, 15.48]
  1 study · 86 participants
  Low

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

Vitamin D (higher dose) + micronutrient(s) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) + micronutrient(s) (moderate certainty).

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  RR 1 [0.9, 1.11]
  2 studies · 126 participants
  Moderate

Vitamin D (higher dose) + micronutrient(s) vs vitamin D (lower dose) + micronutrient(s)

The review found no eligible studies for this question.

• Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found