Findings

What do systematic reviews say?

46 questions · 48 findings · 5 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 29 · 60.4%GRADE not reported 1 · 2.1%Very low 7 · 14.6%Low 7 · 14.6%Moderate 4 · 8.3%High 0 · 0%

Vitamin K vs control

Time to cessation of bleeding · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin K vs control

BMD Z score (lumbar spine) · adults and children with cystic fibrosis

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Vitamin K vs control

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin K vs control

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin K vs control

PIVKA II levels: change in PIVKA II (ng/mL) · adults and children with cystic fibrosis

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Vitamin K vs control

Uncarboxylated osteocalcin: change in carboxylation of osteocalcin (% Glu‐OC) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Serum 25-hydroxyvitamin D level · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Moderate

Vitamin D vs placebo

Total body BMD measured by DEXA (% change from baseline) · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Adverse events · people with sickle cell disease

Vitamin D showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 3.16 [0.14, 72.84]
1 study · 37 participants
Low

Vitamin D vs placebo

Pain frequency or change in pain frequency · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D vs placebo

Acute chest syndrome ( · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

Respiratory infections · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin D vs placebo

HRQoL score (physical functioning) (change from baseline) · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Low

Vitamin D 100,000 IU/month vs 12,000 IU/month

Serum 25-hydroxyvitamin D level · people with sickle cell disease

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Low

Summary of findings: fat‐soluble vitamin E vs control

Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Retinopathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Vitamin E total lipid ratio · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
6 participants
GRADE not reported

Summary of findings: water‐soluble vitamin E vs control

Vitamin E total lipid ratio · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: water‐soluble vitamin E vs control

Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis

Summary of findings: water‐soluble vitamin E may leads to higher vitamin E levels in serum: umol/L compared with control (low certainty).

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 19.74 [13.48, 26]
1 study · 45 participants
Low