Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

62 questions · 70 findings · 8 reviews · Headline outcomes only

No studies found 22 · 31.4%GRADE not reported 5 · 7.1%Very low 14 · 20%Low 15 · 21.4%Moderate 11 · 15.7%High 3 · 4.3%

Vitamin D vs placebo or no intervention

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D showed no clear difference in adverse effect: hypercalciuria As defined by trialistsTime frame:… compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Hypercalcaemia · children under 5 years of age

It is very uncertain whether vitamin D changes adverse effect: hypercalcaemia As defined by trialistsTime frame:… compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Apixaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Rivaroxaban (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Non‐vitamin‐K‐antagonist oral anticoagulants vs placebo

Dabigatran (all doses combined) vs placebo · adults after AMI without an indication for anticoagulation
3 findings from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Adverse effect: hypercalciuria As defined by trialists Time frame: 3 months · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalciuria As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review

Vitamin D (higher dose) vs vitamin D (lower dose)

Hypercalcaemia · children under 5 years of age

Vitamin D (higher dose) showed no clear difference in adverse effect: hypercalcaemia As defined by trialists Time frame:… compared with vitamin D (lower dose) (low certainty).

1 finding from 1 review