Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria
It is very uncertain whether vitamin D plus calcium changes adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria compared with calcium (very low certainty).
1 finding from 1 review
All‐cause mortality
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Growth pattern
1 finding from 1 review
no estimate extracted
1 participants
GRADE not reported
Socioeconomic effects
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pre‐eclampsia · pregnant women and their infants..
Vitamin D supplementation probably leads to lower pre‐eclampsia compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Gestational diabetes · pregnant women and their infants..
Vitamin D supplementation probably leads to lower gestational diabetes compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Severe PPH (≥ 1000 mL) · pregnant women and their infants..
Vitamin D supplementation may leads to lower maternal adverse events: severe postpartum haemorrhage compared with placebo or no intervention (low certainty).
1 finding from 1 review
Maternal adverse event: nephritic syndrome · pregnant women and their infants..
It is very uncertain whether vitamin D supplementation changes maternal adverse event: nephritic syndrome compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Maternal adverse event: hypercalcaemia · pregnant women and their infants..
1 finding from 1 review
Preterm birth · pregnant women and their infants..
Vitamin D supplementation showed no clear difference in preterm birth (less than 37 weeks' gestation) compared with placebo or no intervention (low certainty).
1 finding from 1 review
Low birthweight · pregnant women and their infants..
Vitamin D supplementation probably leads to lower low birthweight (less than 2500 g) compared with placebo or no intervention (moderate certainty).
1 finding from 1 review
Fasting blood glucose (mg/dL) · Adults with diabetes
Meta-analysis of randomised trials of vitamin D supplementation for Fasting glucose (Diabetes patients with normal glucose tolerance): WMD 0.01 (95% CI -0.21 to 0.23), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
2 findings from 1 review
WMD 0.01 [-0.21, 0.23]
Studies not reported
GRADE not reported
WMD -0.3 [-0.9, 0.3]
Studies not reported
GRADE not reported
Femoral neck bone mineral density (FN-BMD) · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in femoral neck, Community-dwelling adults: WMD 1.10 (95% CI 0.40 to 1.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD 1.10 [0.40, 1.90]
8 studies
GRADE not reported
Lumbar spine bone mineral density (BMD) · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in lumbar spine, Community-dwelling adults: WMD 0.10 (95% CI -0.60 to 0.70), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
WMD 0.10 [-0.60, 0.70]
7 studies
GRADE not reported
Non‐vertebral fractures · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, People aged >65 years: RR 0.79 (95% CI 0.63 to 0.99), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Muscle strength · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Performance measures: muscle strength, Older adults: SMD -0.19 (95% CI -0.35 to -0.02), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
SMD -0.19 [-0.35, -0.02]
3 studies
GRADE not reported
Fractures: non-vertebral, non-hip · Older or community-dwelling adults
Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, non-hip, Older women: OR 0.69 (95% CI 0.21 to 1.66), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
OR 0.69 [0.21, 1.66]
2 studies
GRADE not reported
Diastolic blood pressure · Adults (general population)
Meta-analysis of randomised trials of vitamin D supplementation for Diastolic blood pressure: WMD -0.03 (95% CI -1.98 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
WMD -0.03 [-1.98, 1.92]
3 studies
GRADE not reported
Gestational age at birth (weeks) · pregnant women
Meta-analysis of randomised trials of vitamin D supplementation for Mean gestational age at delivery: WMD 0.17 (95% CI -0.16 to 0.51), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
WMD 0.17 [-0.16, 0.51]
2 studies
GRADE not reported