Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · ENT

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%

Tranexamic acid vs placebo (saline solution or sterile water)

Surgical field bleeding score (during surgery or < 30 minutes after surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 772 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Intraoperative blood loss (mL) · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 802 participants
Low

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
8 studies · 664 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Duration of surgery (minutes) Assessed as: total surgical time · adults and children with chronic rhinosinusitis with or without nasal polyps

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 666 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Incomplete surgery · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in incomplete surgery compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
2 studies · 58 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
RD 0
2 studies · 58 participants
Moderate

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 404 participants
Low