Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

83 questions · 84 findings · 6 reviews

No studies found 23 · 27.4%GRADE not reported 0 · 0%Very low 25 · 29.8%Low 20 · 23.8%Moderate 16 · 19%High 0 · 0%

Tramadol in combination with acetaminophen vs placebo

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen probably leads to higher number of participants experiencing any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Tramadol in combination with acetaminophen vs NSAIDs

Number of participants reporting an adverse event · patients with osteoarthritis

Tramadol in combination with acetaminophen showed no clear difference in number of participants experiencing any adverse event compared with NSAIDs (low certainty).

1 finding from 1 review