Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes (8 weeks) · adults with acute affective episodes in bipolar disorder
It is very uncertain whether topiramate as add‐on therapy changes remission with topiramate. Number of participants presenting with a… compared with alternative drug (very low certainty).
1 finding from 1 review
Weight: clinically important change in weight (kg) · people with schizophrenia with antipsychotic‐induced weight gain
1 finding from 1 review
Change in weight (kg) · people with schizophrenia with antipsychotic‐induced weight gain
1 finding from 1 review
Weight: clinically important change in BMI (kg/m2) · people with schizophrenia with antipsychotic‐induced weight gain
1 finding from 1 review
Change in BMI · people with schizophrenia with antipsychotic‐induced weight gain
1 finding from 1 review
Leaving the study early · people with schizophrenia with antipsychotic‐induced weight gain
Topiramate showed no clear difference in leaving the study early: for any reason compared with placebo or no treatment (low certainty).
1 finding from 1 review
Compliance with treatment · people with schizophrenia with antipsychotic‐induced weight gain
1 finding from 1 review
Nausea · people with schizophrenia with antipsychotic‐induced weight gain
Topiramate showed no clear difference in reports of nausea compared with placebo or no treatment (low certainty).
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Patient Global Impression of Change much or very much improved · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
1 finding from 1 review
Withdrawals due to adverse events · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
Topiramate 200 to 400 mg probably leads to higher adverse event withdrawals compared with placebo (moderate certainty).
1 finding from 1 review
RR 3.4 [4.3, 7.1]
1038 participants
Moderate
Serious adverse events · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
Topiramate 200 to 400 mg showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
RR 0.9 [0.6, 1.3]
1586 participants
Moderate
Death · neuropathic pain (two studies found in painful diabetic neuropathy, and one in lumbar radiculopathy)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
1 finding from 1 review
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: change in scores from baseline to endpoint (12 weeks) on symptom rating scales in the treatment of manic and mixed episodes Lower scores indicate improvement · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found