Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate as monotherapy showed no clear difference in acceptability with topiramate (12 weeks) Number of participants… compared with an alternative drug (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
Topiramate as add‐on therapy showed no clear difference in acceptability with topiramate (endpoint: 12 weeks) Number of… compared with placebo (low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
Topiramate as add‐on therapy showed no clear difference in response to treatment with topiramate. Number of participants… compared with placebo (low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Acceptability. Participants experiencing troublesome adverse effects of any nature · adults with acute affective episodes in bipolar disorder
It is very uncertain whether topiramate as add‐on therapy changes acceptability with topiramate (8 weeks) Number of participants… compared with alternative drug (very low certainty).
1 finding from 1 review
Response to treatment with topiramate. Number of participants experiencing a 50% reduction or greater in mean score from baseline to end of treatment on symptom rating scales in manic and mixed episodes · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · adults with acute affective episodes in bipolar disorder
It is very uncertain whether topiramate as add‐on therapy changes response to treatment with topiramate. Number of participants… compared with alternative drug (very low certainty).
1 finding from 1 review
Remission · adults with acute affective episodes in bipolar disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission with topiramate. Number of participants presenting with a rating scale score within the normal range at the endpoint in depressive episodes (8 weeks) · adults with acute affective episodes in bipolar disorder
It is very uncertain whether topiramate as add‐on therapy changes remission with topiramate. Number of participants presenting with a… compared with alternative drug (very low certainty).
1 finding from 1 review
Proportion of responders (at least 50% seizure frequency reduction in PGTCS) · people with juvenile myoclonic epilepsy
It is very uncertain whether topiramate changes proportion of responders (at least 50% seizure frequency reduction… compared with placebo (very low certainty).
1 finding from 1 review
Proportion of participants who experienced at least one AE and individual AEs · people with juvenile myoclonic epilepsy
1 finding from 1 review
Seizure freedom · people with juvenile myoclonic epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found