Question · asked by 1 review
Topiramate vs placebo or no treatment: Change in weight (kg)
- Population
- people with schizophrenia with antipsychotic‐induced weight gain
- Intervention
- Topiramate
- Comparison
- placebo or no treatment
- Outcome
- Change in weight (kg)
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Topiramate vs placebo or no treatment Weight: average endpoint/change in weight (kg) · people with schizophrenia with antipsychotic‐induced weight gain Pharmacological interventions for prevention of weight gain in people with schizophrenia (2022) · Cochrane Headline outcomes only | no estimate extracted | 3 studies · 168 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for prevention of weight gain in people with schizophrenia 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.