Findings

What do systematic reviews say?

18 questions · 20 findings · 3 reviews

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No studies found 4 · 20%GRADE not reported 0 · 0%Very low 3 · 15%Low 7 · 35%Moderate 2 · 10%High 4 · 20%

Topical NSAIDs vs topical placebo

All topical NSAIDs Local adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 6125 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Systemic adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
38 studies · 5372 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Withdrawals ‐ adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 5790 participants
High

Topical NSAIDs vs topical placebo

At least 50% reduction in pain · adults with strains, sprains, or muscle pull

2 findings from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 314 participants
High
Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 348 participants
Moderate

Topical NSAIDs vs topical placebo

Clinical success (eg 50% reduction in pain) Chronic conditions · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 241 participants
Moderate

Topical NSAIDs vs topical placebo

Serious adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Topical NSAIDs vs placebo

Pain intensity (0‐10cm visual analogue scale) · Adults with lateral elbow pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 153 participants
Very low

Topical NSAIDs vs placebo

Treatment success Fair, good or excellent effectiveness · Adults with lateral elbow pain

Topical NSAIDs may leads to higher treatment success Fair, good or excellent effectiveness compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
RR 1.49 [1.04, 2.14]
1 study · 85 participants
Low

Topical NSAIDs vs placebo

Function/disability · Adults with lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical NSAIDs vs placebo

Quality of life · Adults with lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical NSAIDs vs placebo

Withdrawals due to adverse events · Adults with lateral elbow pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 185 participants
Low

Topical NSAIDs vs placebo

Adverse events · Adults with lateral elbow pain

Topical NSAIDs showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
RR 1.55 [0.2, 12.14]
3 studies · 153 participants
Low

Topical NSAIDs vs control

Reduction in pain intensity · analgesia in traumatic corneal abrasions

The review found no eligible studies for this question.

1 finding from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical NSAIDs vs control

Rescue analgesia · analgesia in traumatic corneal abrasions

Topical NSAIDs may leads to lower use of rescue oral analgesia at 24 hours compared with control (low certainty).

2 findings from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
RR 0.46 [0.34, 0.61]
4 studies · 481 participants
Low
Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical NSAIDs vs control

Proportion of abrasions healed after 24 hours · analgesia in traumatic corneal abrasions

Topical NSAIDs showed no clear difference in proportion of abrasions healed after 24 hours compared with control (low certainty).

1 finding from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
RR 1 [0.81, 1.23]
1 study · 28 participants
Low

Topical NSAIDs vs control

Proportion of abrasions healed after 48 hours · analgesia in traumatic corneal abrasions

Topical NSAIDs showed no clear difference in proportion of abrasions healed after 48 hours compared with control (low certainty).

1 finding from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
RR 1 [0.88, 1.14]
1 study · 28 participants
Low

Topical NSAIDs vs control

Complications of corneal abrasion · analgesia in traumatic corneal abrasions

It is very uncertain whether topical NSAIDs changes complications of corneal abrasion compared with control (very low certainty).

1 finding from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
RR 0.44 [0.07, 2.96]
6 studies · 609 participants
Very low

Topical NSAIDs vs control

Adverse drug events · analgesia in traumatic corneal abrasions

It is very uncertain whether topical NSAIDs changes drug‐related adverse events compared with control (very low certainty).

1 finding from 1 review

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions 2017 · Cochrane Headline outcomes only
RR 2.95 [0.32, 27.6]
2 studies · 163 participants
Very low