Cochrane · systematic review · CD009781

Topical non‐steroidal anti‐inflammatory drugs for analgesia in traumatic corneal abrasions

Wakai, A, Lawrenson, JG, Lawrenson, AL, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 2 · 28.6%Ungraded 0 · 0%Very low 2 · 28.6%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Topical NSAIDs compared to control for analgesia in traumatic corneal abrasions

Population: analgesia in traumatic corneal abrasions

7 questions

Outcome	Effect	Evidence	Status / GRADE
Participant‐reported pain intensity reduction of 30%/50% or greater at 24 hours Topical NSAIDs vs control	no estimate extracted	NR	No studies
Use of rescue oral analgesia at 24 hours Topical NSAIDs vs control	RR 0.46 [0.34, 0.61]	4 studies · 481 participants	Low Downgraded: risk of bias
Use of rescue oral analgesia at 48/72 hours Topical NSAIDs vs control	no estimate extracted	NR	No studies
Proportion of abrasions healed after 24 hours Topical NSAIDs vs control	RR 1 [0.81, 1.23]	1 study · 28 participants	Low Downgraded: risk of bias
Proportion of abrasions healed after 48 hours Topical NSAIDs vs control	RR 1 [0.88, 1.14]	1 study · 28 participants	Low Downgraded: risk of bias
Complications of corneal abrasion Topical NSAIDs vs control	RR 0.44 [0.07, 2.96]	6 studies · 609 participants	Very low Downgraded: risk of bias
Drug‐related adverse events Topical NSAIDs vs control	RR 2.95 [0.32, 27.6]	2 studies · 163 participants	Very low Downgraded: risk of bias