Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

634 questions · 675 findings · 72 reviews

No studies found 155 · 23%GRADE not reported 50 · 7.4%Very low 144 · 21.3%Low 166 · 24.6%Moderate 119 · 17.6%High 41 · 6.1%

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Cardiac events (fatal) · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in cardiac events (fatal) compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Cardiac events (non fatal) · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in cardiac events (non fatal) compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Peritonitis · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs conventional therapy

Adverse events (episodes of peritonitis) ‐ not treated with an aminoglycoside · patients receiving PD

Angiotensin‐converting enzyme inhibitors (ACEi) showed no clear difference in adverse events (episodes of peritonitis) ‐ not treated with an… compared with conventional therapy (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in heart failure hospitalisation (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

All‐cause mortality (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in cardiovascular mortality (RR) Median compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Time to first hospitalisation for heart failure during · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in heart failure hospitalisation, first (RR) Range of compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in hyperkalaemia Range of compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

All‐cause mortality (RR) Range of · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) leads to lower all‐cause mortality (RR) Range of compared with usual care (high certainty).

1 finding from 1 review

Discontinuation by no treatment/placebo of antihypertensives vs continuation

Fatal or nonfatal myocardial infarction · Older adults, 50 years and older

It is very uncertain whether discontinuation by no treatment/placebo of antihypertensives changes myocardial infarction (fatal and nonfatal) compared with continuation (very low certainty).

1 finding from 1 review