Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 66.7%High 1 · 33.3%

Serious adverse events · High‐risk individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 1.03 [0.79, 1.33]
1 study · 3168 participants
Moderate

Serious adverse events · patients with initial ART

TDF showed no clear difference in serious adverse events compared with AZT (high certainty).

1 finding from 1 review

Serious adverse events · High‐risk HIV‐uninfected individuals (including serodiscordant couples, men who have sex with men and sex workers)

TDF+ FTC showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Antiretroviral pre‐exposure prophylaxis (PrEP) for preventing HIV in high‐risk individuals 2012 · Cochrane Headline outcomes only
RR 1 [0.83, 1.19]
3 studies · 6862 participants
Moderate