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Evidence found and GRADE certainty

347 questions · 355 findings · 51 reviews

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No studies found 135 · 38%GRADE not reported 45 · 12.7%Very low 90 · 25.4%Low 63 · 17.7%Moderate 15 · 4.2%High 7 · 2%

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Prevalence of pain - 1 day · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

Root-end resection (with or without root-end filling; surgical… may leads to higher prevalence of pain - 1 day (participants reporting pain) compared with root canal retreatment (non-surgical/orthograde) (low certainty).

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Healing - 1 year · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

It is very uncertain whether root-end resection (with or without root-end filling; surgical… changes healing - 1 year compared with root canal retreatment (non-surgical/orthograde) (very low certainty).

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Overall survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Disease-free survival · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Resectability · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Quality of life · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Adverse events · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Complete remission · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Partial reduction · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Primary surgical intervention (curettage, peripheral osteotomy, or resection) vs Primary non-surgical intervention (intralesional corticosteroids, subcutaneous calcitonin, interferon alpha, or imatinib)

Recurrence · Patients with a pathological diagnosis of central giant cell granuloma (CGCG) of the jaws

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotics without surgical intervention (with or without analgesics) vs Matched placebo without surgical intervention (with or without analgesics)

Outcome not reported · Adults with symptomatic apical periodontitis or acute apical abscess

The review found no eligible studies for this question.

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Death or severe disability (mRS > 4) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression leads to lower death or severe disability (mRS > 4) at 6 to 12 months compared with medical treatment alone (high certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Death or moderate disability (mRS > 3) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression probably leads to lower death or moderate disability (mRS > 3) at 6 to 12 months compared with medical treatment alone (moderate certainty).

1 finding from 1 review

SUMMARY OF FINDINGS FOR DECOMPRESSION vs medical treatment

Severe disability (mRS = 5) at 6 to 12 months · malignant cerebral oedema after ischaemic stroke

Summary of findings table ‐ surgical decompression showed no clear difference in severe disability (mRS = 5) at 6 to 12 months compared with medical treatment alone (low certainty).

1 finding from 1 review