Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 4 · 57.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 42.9%Moderate 0 · 0%High 0 · 0%

BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and low bone mass

Summary of findings – denosumab showed no clear difference in BMD Z score (total hip/femoral neck) compared with placebo (low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
MD 0.05
1 study · 63 participants
Low

BMD Z score (lumbar spine) · adults with β‐thalassaemia and low bone mass

Summary of findings – denosumab showed no clear difference in BMD Z score (lumbar spine) compared with placebo (low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Low

BMD Z score (wrist) · adults with β‐thalassaemia and low bone mass

Summary of findings – denosumab showed no clear difference in BMD Z score (wrist) compared with placebo (low certainty).

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Low

Incidence of fractures · adults with β‐thalassaemia and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Mobility · adults with β‐thalassaemia and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Quality of life · adults with β‐thalassaemia and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse effects of treatment · adults with β‐thalassaemia and low bone mass

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for osteoporosis in people with beta‐thalassaemia 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found