Findings

What do systematic reviews say?

607 questions · 641 findings · 77 reviews

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No studies found 114 · 17.8%GRADE not reported 25 · 3.9%Very low 170 · 26.5%Low 175 · 27.3%Moderate 123 · 19.2%High 34 · 5.3%

Corticosteroids vs no corticosteroid use

Incidence of any serious adverse effects attributable to the administration of corticosteroids · children diagnosed with Kawasaki disease

1 finding from 1 review

Corticosteroids for the treatment of Kawasaki disease in children 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 737 participants
Moderate

Steroids vs lubricants

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3654 participants
Moderate

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
MD 0.37
5 studies · 353 participants
Low

Steroids vs cyclosporine A

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
SMD 0.05
6 studies · 465 participants
Low

Steroids vs cyclosporine A

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with cyclosporine A (very low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
MD 5.8
1 study · 69 participants
Very low

Steroids vs cyclosporine A

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with cyclosporine A (very low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
RR 1.45 [0.25, 8.33]
4 studies · 331 participants
Very low

Steroids vs cyclosporine A

Adverse effect: cataract · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Steroids vs lubricants

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Steroids vs lubricants

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids may leads to higher change in TBUT (seconds) (longer is favored) compared with lubricants (low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
MD 0.7 [0.06, 1.34]
7 studies · 587 participants
Low

Steroids vs lubricants

Change in fluorescein corneal staining scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in fluorescein corneal staining scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3583 participants
Moderate

Steroids vs lubricants

Change in tear osmolarity (mOsm/kg) (lower is favored) · people with dry eye

It is very uncertain whether steroids changes change in tear osmolarity (mOsm/kg) (lower is favored) compared with lubricants (very low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
MD 1.6
1 study · 40 participants
Very low

Steroids vs lubricants

Adverse effect: incident elevated IOP ( · people with dry eye

It is very uncertain whether steroids changes adverse effect: incident elevated IOP ( compared with lubricants (very low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
RR 5.96 [1.3, 27.38]
8 studies · 2264 participants
Very low

Steroids vs lubricants

Adverse effect: cataract · people with dry eye

It is very uncertain whether steroids changes adverse effect: new cataract formation ( compared with lubricants (very low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
RR 0.34 [0.01, 8.22]
3 studies · 1205 participants
Very low

Steroids vs cyclosporine A

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 465 participants
Low

Steroids vs cyclosporine A

Change in patient‐reported quality of life scores · people with dry eye

The review found no eligible studies for this question.

1 finding from 1 review

Topical corticosteroids for dry eye 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhaled corticosteroids vs placebo

Open‐label use of systemic corticosteroids · preterm infants

It is very uncertain whether inhaled corticosteroids changes open‐label use of systemic corticosteroids compared with placebo (very low certainty).

1 finding from 1 review

Late (≥ 7 days) inhaled corticosteroids to reduce bronchopulmonary dysplasia in preterm infants 2022 · Cochrane Headline outcomes only
RR 0.51 [0.26, 1]
4 studies · 74 participants
Very low

Steroids vs no specific treatment

Complete remission · minimal change disease in adults with nephrotic syndrome

It is very uncertain whether steroids changes complete remission Time frame: to 77 months compared with no specific treatment (very low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.44 [0.95, 2.19]
1 study · 28 participants
Very low

Steroids vs no specific treatment

Complete or partial remission · minimal change disease in adults with nephrotic syndrome

It is very uncertain whether steroids changes complete or partial remission Time frame: to 77 months compared with no specific treatment (very low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.38 [0.98, 1.95]
1 study · 28 participants
Very low

Steroids vs no specific treatment

Relapse · minimal change disease in adults with nephrotic syndrome

It is very uncertain whether steroids changes relapse during compared with no specific treatment (very low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.75 [0.48, 1.17]
1 study · 28 participants
Very low

Steroids vs no specific treatment

Adverse events: avascular necrosis · minimal change disease in adults with nephrotic syndrome

It is very uncertain whether steroids changes adverse events: avascular necrosis compared with no specific treatment (very low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 3 [0.13, 67.91]
1 study · 28 participants
Very low