Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

121 questions · 128 findings · 12 reviews

No studies found 34 · 26.6%GRADE not reported 2 · 1.6%Very low 37 · 28.9%Low 38 · 29.7%Moderate 15 · 11.7%High 2 · 1.6%

Topical antibiotics with steroids vs topical antibiotics

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with chronic suppurative otitis media or ear discharge

Topical antibiotics with steroids may leads to lower resolution of ear discharge at between 1 to 2 weeks compared with topical antibiotics alone (low certainty).

2 findings from 1 review

Topical antibiotics with steroids vs topical antibiotics

Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with chronic suppurative otitis media or ear discharge

The review found no eligible studies for this question.

2 findings from 1 review

Topical antibiotics with steroids vs topical antibiotics

Discomfort/pain · people (of any age) with chronic suppurative otitis media or ear discharge

It is very uncertain whether topical antibiotics with steroids changes ear pain or discomfort at 14 weeks compared with topical antibiotics alone (very low certainty).

1 finding from 1 review

Topical antibiotics with steroids vs topical antibiotics

Suspected ototoxicity: dizziness/vertigo/balance · people (of any age) with chronic suppurative otitis media or ear discharge

It is very uncertain whether topical antibiotics with steroids changes suspected ototoxicity: dizziness/vertigo/balance compared with topical antibiotics alone (very low certainty).

1 finding from 1 review

Topical corticosteroids vs Another topical agent or placebo

Duration to heal oral ulcerations after initiation of treatment · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs Another topical agent or placebo

Healing of ulceration · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs Another topical agent or placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs Another topical agent or placebo

Incidence and recurrence after healing of ulcers · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review
  • No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
    0 studies
    No studies found

Topical corticosteroids vs placebo or no treatment

Complete resolution of phimosis · boys up to 18 years old with phimosis

Topical corticosteroids may leads to higher complete resolution of phimosis compared with placebo or no treatment (low certainty).

2 findings from 1 review

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in patient‐reported symptom scores (lower is favored) · people with dry eye

Steroids showed no clear difference in change in patient‐reported symptom scores (lower is favored) compared with lubricants (moderate certainty).

1 finding from 1 review

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review