Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

109 questions · 110 findings · 14 reviews

No studies found 16 · 14.5%GRADE not reported 16 · 14.5%Very low 25 · 22.7%Low 16 · 14.5%Moderate 25 · 22.7%High 12 · 10.9%

Statins vs placebo

Mean pressure gradient (mmHg) Better indicated by lower scores. · patients with aortic valve stenosis

Statin showed no clear difference in mean pressure gradient (mmHg) Better indicated by lower scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Valve area (cm2) Better indicated by higher scores. · patients with aortic valve stenosis

Statin showed no clear difference in valve area (cm2) Better indicated by higher scores. compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Aortic jet velocity (m/s) · patients with aortic valve stenosis

Statin showed no clear difference in aortic jet velocity (m/s) compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

All cardiovascular death · patients with aortic valve stenosis

Statin showed no clear difference in death from cardiovascular cause compared with placebo (low certainty).

1 finding from 1 review

Statins vs placebo

Hospitalisation for any reason · patients with aortic valve stenosis

It is very uncertain whether statin changes hospitalisation for any reason compared with placebo (very low certainty).

1 finding from 1 review

Statins vs placebo

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Total VTE · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower all cases of VTE compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Any MI · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower any MI compared with placebo (moderate certainty).

1 finding from 1 review