What do systematic reviews say?

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants infectious at day 3‐4 compared with no primaquine, with artemisinin partner, (low certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.2 [0.02, 1.68]
  1 study · 101 participants
  Low
• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.18 [0.02, 1.41]
  2 studies · 181 participants
  Low

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 3‐4, by PCR compared with no primaquine, with artemisinin partner, (low certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.92 [0.75, 1.13]
  2 studies · 290 participants
  Low

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

Single dose primaquine at 0.75 mg/kg leads to lower participants with gametocytes at day 8, by PCR compared with no primaquine, with artemisinin partner, (high certainty).

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  RR 0.31 [0.23, 0.43]
  5 studies · 793 participants
  High

Single dose primaquine at 0.75 mg/kg vs no primaquine, with artemisinin partner,

• Primaquine or other 8‐aminoquinolines for reducing Plasmodium falciparum transmission 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 106 participants
  GRADE not reported