new carious lesions or fillings · Children with dental caries in permanent (first) molars
The review reported no significant result for SDF; no effect estimate or GRADE rating was reported.
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF plus potassium iodide had a 52% preventative fraction; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available.
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF plus fluoride varnish did not significantly differ from ART plus fluoride varnish for oral health-related quality of life (MD 0.16, 95% CI -0.1 to 0.42; ungraded).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
It is very uncertain whether silver diamine fluoride (SDF) changes aesthetics compared with fluoride varnish (very low certainty).
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, people complained about a transient bitter taste associated with SDF (with no associated data), with no other adverse effects. In another study, there were no adverse effects. No studies reported this…
2 studies · 336 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, 115 of 118 children had black stains on teeth treated with SDF; there were no other adverse effects or allergic reactions. In 1 study, the rate of adverse effects reported by caregiver and person who…
3 studies · 482 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
Cleary 2022 reported no significant differences (P > 0.05) in parental acceptability, satisfaction, and preference between treatments at 6 and 12 months; at 12 months children in the restoration arm felt happier with…
1 study
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
Gao 2019 noted that "arrested lesions were stained black" (reported with no associated data). No other adverse effects observed, and no reports from parents of systemic disease.
1 study · 1070 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
2 findings from 1 review
1 study reported no adverse effects. 1 study reported a white discolouration of the gingiva adjacent to surfaces treated with SDF (116 surfaces) as well as redness (4 surfaces), and mild ulceration (2 surfaces). In…
2 studies · 316 participants
Very low
1 study reported 3 adverse effects in the first 48 hours. Of these, 1 effect in SDF group was possibly related to treatment (spot on corner of lip that looked like a burn), and 2 effects in placebo group were possibly…
3 studies · 983 participants
Very low
Adverse effects · Children and adults (with or without carious lesions)
1 finding from 1 review
In 1 study, black or brown staining on treated lesions was more common after SDF (OR 3.19, 95% CI 1.95 to 5.23), with no other adverse effects. 1 study reported complaints of a transient bitter taste with SDF use (with…
3 studies · 980 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
1 finding from 1 review
1 study reported that "only 19 (7%) [older adult participants] raised a complaint about the interventions at the 30-mo [month] examination, and half of them complained of black stain on the treated root surfaces." No…
1 study · 43 participants
Very low
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review