Findings

What do systematic reviews say?

13 questions · 13 findings · 2 reviews · Acute Respiratory Infections

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 38.5%Low 8 · 61.5%Moderate 0 · 0%High 0 · 0%

Nebulised hypertonic saline vs nebulised 0.9% saline

Length of hospital stay · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
21 studies · 2479 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Adverse events Assessed by investigators or reported by parents · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
27 studies · 4416 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Clinical severity score (post‐treatment) at day 1 · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 893 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Clinical severity score (post‐treatment) at day 2 · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 907 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Clinical severity score (post‐treatment) at day 3 · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 785 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Annual hospitalisation rates · infants up to 24 months of age with acute bronchiolitis

Nebulised hypertonic saline may leads to lower rate of hospitalisation compared with nebulised 0.9% saline (low certainty).

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
RR 0.87 [0.78, 0.97]
8 studies · 1760 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Hospital readmission · infants up to 24 months of age with acute bronchiolitis

Nebulised hypertonic saline showed no clear difference in rate of readmission to hospital compared with nebulised 0.9% saline (low certainty).

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
RR 0.83 [0.55, 1.25]
6 studies · 1084 participants
Low

Nebulised hypertonic saline vs nebulised 0.9% saline

Number of days to resolution of symptoms and signs (wheezing) · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 205 participants
Very low

Nebulised hypertonic saline vs nebulised 0.9% saline

Number of days to resolution of symptoms and signs (cough) · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 363 participants
Very low

Nebulised hypertonic saline vs nebulised 0.9% saline

Number of days to resolution of symptoms and signs(pulmonary moist crackles) · infants up to 24 months of age with acute bronchiolitis

1 finding from 1 review

Nebulised hypertonic saline solution for acute bronchiolitis in infants 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 205 participants
Very low

Normal saline plus standard treatment vs usual care

Mean days to wellness Patient reports · patients with acute upper respiratory tract infections

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 111 participants
Very low

Normal saline plus standard treatment vs usual care

Antibiotic usage Patient‐reported usage · patients with acute upper respiratory tract infections

It is very uncertain whether normal saline plus standard treatment changes antibiotic usage Patient‐reported usage compared with standard treatment alone (very low certainty).

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
OR 0.65 [0.29, 1.46]
2 studies · 422 participants
Very low

Normal saline plus standard treatment vs usual care

Sore throat · patients with acute upper respiratory tract infections

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 390 participants
Low