Findings

What do systematic reviews say?

135 questions · 137 findings · 14 reviews

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No studies found 40 · 29.2%GRADE not reported 16 · 11.7%Very low 44 · 32.1%Low 27 · 19.7%Moderate 10 · 7.3%High 0 · 0%

Hypertonic saline 7% vs xylitol

FEV1 % predicted: relative change from baseline · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Hypertonic saline 7% vs xylitol

FEV1 · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

LCI · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

All‐cause mortality · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

Measures of sputum clearance · adults with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline 7% vs xylitol

Pulmonary exacerbations · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Low

Hypertonic saline 7% vs xylitol

Adverse events: serious adverse events · adults with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 89 participants
Very low

Saline vs expectant management

Manual removal of the placenta · management of retained placenta

Saline solution showed no clear difference in manual removal of the placenta compared with expectant management (moderate certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 0.93 [0.8, 1.1]
5 studies · 445 participants
Moderate

Saline vs expectant management

Maternal death · management of retained placenta

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 87 participants
Very low

Saline vs expectant management

Severe PPH (≥ 1000 mL) · management of retained placenta

It is very uncertain whether saline solution changes severe PPH (≥ 1000 mL) compared with expectant management (very low certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 0.73 [0.17, 3.11]
1 study · 122 participants
Very low

Saline vs expectant management

Blood transfusion · management of retained placenta

It is very uncertain whether saline solution changes blood transfusion compared with expectant management (very low certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 0.41 [0.1, 1.73]
3 studies · 277 participants
Very low

Saline vs expectant management

Addition of therapeutic uterotonics · management of retained placenta

The review found no eligible studies for this question.

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline vs expectant management

Need for antibiotics · management of retained placenta

It is very uncertain whether saline solution changes need for treatment with antibiotics (infection) compared with expectant management (very low certainty).

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
RR 0.48 [0.09, 2.54]
1 study · 176 participants
Very low

Saline vs expectant management

Maternal postpartum anaemia (haemoglobin 24–48 hours postpartum) · management of retained placenta

1 finding from 1 review

Umbilical vein injection for management of retained placenta 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 163 participants
Very low

Normal saline plus standard treatment vs usual care

Mean days to wellness Patient reports · patients with acute upper respiratory tract infections

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 111 participants
Very low

Normal saline plus standard treatment vs usual care

Antibiotic usage Patient‐reported usage · patients with acute upper respiratory tract infections

It is very uncertain whether normal saline plus standard treatment changes antibiotic usage Patient‐reported usage compared with standard treatment alone (very low certainty).

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
OR 0.65 [0.29, 1.46]
2 studies · 422 participants
Very low

Normal saline plus standard treatment vs usual care

Sore throat · patients with acute upper respiratory tract infections

1 finding from 1 review

Saline nasal irrigation for acute upper respiratory tract infections 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 390 participants
Low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Individual symptom scores ‐ not measured · allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Adverse effects ‐ epistaxis · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Health‐related quality of life (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low