Findings

What do systematic reviews say?

135 questions · 137 findings · 14 reviews

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No studies found 40 · 29.2%GRADE not reported 16 · 11.7%Very low 44 · 32.1%Low 27 · 19.7%Moderate 10 · 7.3%High 0 · 0%

Hypertonic saline vs sodium‐2‐mercaptoethane sulphonate (Mistabron®)

Pulmonary exacerbations · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Hypertonic saline vs sodium‐2‐mercaptoethane sulphonate (Mistabron®)

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Hypertonic saline vs mannitol

FEV1: short term · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Hypertonic saline vs mannitol

FEV1 (L) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

LCI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

All‐cause mortality · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

Measures of sputum clearance · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Hypertonic saline vs mannitol

Pulmonary exacerbations · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs mannitol

Adverse events · adults and children with cystic fibrosis

1 finding from 1 review

Nebulised hypertonic saline for cystic fibrosis 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Mortality (short‐term) · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes mortality (short‐term) compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 0.33
2 studies · 70 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Mortality at 6 months · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes mortality at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 0.84 [0.46, 1.55]
2 studies · 85 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Glasgow Outcome Scale: poor outcome at 6 months · people with acute traumatic brain injury

It is very uncertain whether hypertonic saline changes glasgow Outcome Scale: poor outcome at 6 months compared with other intracranial pressure‐lowering agents (very low certainty).

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
RR 1.09 [0.82, 1.44]
2 studies · 85 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Uncontrolled ICP during treatment · people with acute traumatic brain injury

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 287 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

A rebound phenomenon during treatment · people with acute traumatic brain injury

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Hypertonic saline vs other intracranial pressure‐lowering agents

Pulmonary oedema · people with acute traumatic brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hypertonic saline vs other intracranial pressure‐lowering agents

Acute renal failure during treatment · people with acute traumatic brain injury

The review found no eligible studies for this question.

1 finding from 1 review

Hypertonic saline versus other intracranial pressure–lowering agents for people with acute traumatic brain injury 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline rinse vs usual or supportive care

Duration of ICU stay · Critically ill patients receiving mechanical ventilation in ICU

Saline rinse showed no clear difference in duration of ICU stay compared with usual care (no rinse); GRADE not reported.

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
MD -1.17 [-3.95, 1.60]
2 studies · 324 participants
GRADE not reported

Saline rinse vs usual or supportive care

Duration of mechanical ventilation · Critically ill patients receiving mechanical ventilation in ICU

Saline rinse showed no clear difference in duration of mechanical ventilation compared with usual care (no rinse); GRADE not reported.

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
MD -0.40 [-2.55, 1.75]
2 studies · 324 participants
GRADE not reported

Saline rinse vs usual or supportive care

Incidence of VAP · Critically ill patients receiving mechanical ventilation in ICU

Saline rinse led to lower incidence of VAP compared with usual care (no rinse); GRADE not reported.

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
RR 0.60 [0.39, 0.91]
2 studies · 324 participants
GRADE not reported

Saline rinse vs usual or supportive care

All‐cause mortality · Critically ill patients receiving mechanical ventilation in ICU

Saline rinse showed no clear difference in mortality compared with usual care (no rinse); GRADE not reported.

1 finding from 1 review

Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
RR 1.10 [0.87, 1.39]
2 studies · 324 participants
GRADE not reported