Findings

What do systematic reviews say?

9 questions · 9 findings · 2 reviews · Infectious Diseases

No studies found 2 · 22.2%GRADE not reported 0 · 0%Very low 3 · 33.3%Low 2 · 22.2%Moderate 2 · 22.2%High 0 · 0%

total treatment failure · patients with human Brucellosis

Doxycycline+Rifampicin probably leads to higher total treatment failure compared with doxycycline+Streptomycin (moderate certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
RR 1.91 [1.07, 3.42]
7 studies · 567 participants
Moderate

Minor adverse drug reactions · patients with human Brucellosis

Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with doxycycline+Streptomycin (low certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
RR 1.38 [0.99, 1.92]
5 studies · 473 participants
Low

total treatment failure · patients with human Brucellosis

Doxycycline+Rifampicin showed no clear difference in total treatment failure compared with quinolones+Rifampicin (moderate certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
OR 0.94 [0.45, 1.98]
3 studies · 181 participants
Moderate

Minor adverse drug reactions · patients with human Brucellosis

Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with quinolones+Rifampicin (low certainty).

1 finding from 1 review

Antibiotics for treating human brucellosis 2012 · Cochrane Headline outcomes only
RR 1.8 [0.78, 4.18]
4 studies · 296 participants
Low

Treatment failure · adults with scrub typhus

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 78 participants
Very low

Resolution of fever within 48 hours · adults with scrub typhus

It is very uncertain whether rifampicin changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
RR 1.68 [1.1, 2.57]
1 study · 78 participants
Very low

Resolution of fever within 5 days · adults with scrub typhus

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Time to defervescence · adults with scrub typhus

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 78 participants
Very low

Serious adverse events · adults with scrub typhus

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics for treating scrub typhus 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found