Quality of life · people with neovascular AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Any adverse outcome · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Low
Number of anti‐VEGF injections · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with neovascular AMD
Radiotherapy combined with anti‐VEGF probably leads to higher loss of 3 or more lines of best‐corrected visual acuity Measured… compared with anti‐VEGF alone (moderate certainty).
1 finding from 1 review
RR 2.11 [1.4, 3.17]
Studies not reported
Moderate
Change in visual acuity (logMAR) ‐ 12 months (negative is better) · people with neovascular AMD
Radiotherapy combined with anti‐VEGF showed no clear difference in change in best corrected visual acuity (logMAR units) Measured using… compared with anti‐VEGF alone (low certainty).
1 finding from 1 review
mean difference 0.1
Studies not reported
Low
Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).
1 finding from 1 review
Groin recurrence · patients with Early Vulvar Cancer
Primary Groin Radiotherapy showed no clear difference in groin recurrence compared with primary Groin Surgery (low certainty).
1 finding from 1 review
Disease specific mortality · patients with Early Vulvar Cancer
Primary Groin Radiotherapy showed no clear difference in disease specific mortality compared with primary Groin Surgery (low certainty).
1 finding from 1 review
Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in total mortality compared with surgery alone; GRADE not reported.
1 finding from 1 review
HR 0.83 [0.64, 1.07]
1 study
GRADE not reported
Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
Pre-operative radiotherapy (plus surgery) showed no clear difference in locoregional control compared with surgery alone; GRADE not reported.
1 finding from 1 review
RR 0.63 [0.28, 1.46]
1 study
GRADE not reported
Overall survival · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes overall survival compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis
1 finding from 1 review
Adverse events · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Adverse events (moderate) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Adverse events (severe) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).
1 finding from 1 review
Progression‐free survival ‐ not measured · people with single or solitary brain metastasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life (HRQoL) · people with single or solitary brain metastasis
1 finding from 1 review
no estimate extracted
1 study · 1 participants
Very low
Overall survival · people with single or solitary brain metastasis
Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in overall survival compared with stereotactic radiosurgery plus WBRT (low certainty).
1 finding from 1 review
Adverse events (moderate) · people with single or solitary brain metastasis
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (moderate) compared with stereotactic radiosurgery plus WBRT (very low certainty).
1 finding from 1 review
Progression‐free survival · people with single or solitary brain metastasis
Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in progression‐free survival compared with stereotactic radiosurgery plus WBRT (low certainty).
1 finding from 1 review