What do systematic reviews say?

Radical prostatectomy vs watchful waiting

Radical prostatectomy probably leads to lower time to death from any causeMedian compared with watchful waiting (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.79 [0.7, 0.9]
  3 studies · 1537 participants
  Moderate

Radical prostatectomy vs active monitoring

Radical prostatectomy probably leads to lower time to disease progressionMedian compared with active monitoring (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.39 [0.27, 0.56]
  1 study · 1098 participants
  Moderate

Radical prostatectomy vs active monitoring

Radical prostatectomy probably leads to lower incidence of metastatic diseaseMedian compared with active monitoring (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  RR 0.39 [0.21, 0.73]
  1 study · 1098 participants
  Moderate

Radical prostatectomy vs active monitoring

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 856 participants
  Moderate

Radical prostatectomy vs active monitoring

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 782 participants
  Low

Radical prostatectomy vs active monitoring

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 756 participants
  Low

Radical prostatectomy vs watchful waiting

Radical prostatectomy probably leads to lower time to death from prostate cancerMedian compared with watchful waiting (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.57 [0.44, 0.73]
  2 studies · 1426 participants
  Moderate

Radical prostatectomy vs watchful waiting

Radical prostatectomy may leads to lower time to disease progressionMedian compared with watchful waiting (low certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.43 [0.35, 0.54]
  2 studies · 1426 participants
  Low

Radical prostatectomy vs watchful waiting

Radical prostatectomy probably leads to lower time to metastatic diseaseMedian compared with watchful waiting (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.56 [0.46, 0.7]
  2 studies · 1426 participants
  Moderate

Radical prostatectomy vs watchful waiting

Radical prostatectomy showed no clear difference in quality of life compared with watchful waiting (low certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  RR 1 [0.85, 1.16]
  1 study · 339 participants
  Low

Radical prostatectomy vs watchful waiting

Radical prostatectomy may leads to higher urinary function: incontinence compared with watchful waiting (low certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  RR 3.97 [2.34, 6.74]
  1 study · 731 participants
  Low

Radical prostatectomy vs watchful waiting

Radical prostatectomy may leads to higher sexual function: erectile dysfunction compared with watchful waiting (low certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  RR 2.67 [1.63, 4.38]
  1 study · 731 participants
  Low

Radical prostatectomy vs active monitoring

Radical prostatectomy showed no clear difference in time to death from any causeMedian compared with active monitoring (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.93 [0.65, 1.33]
  1 study · 1098 participants
  Moderate

Radical prostatectomy vs active monitoring

Radical prostatectomy showed no clear difference in time to death from prostate cancerMedian compared with active monitoring (moderate certainty).

• Radical prostatectomy versus deferred treatment for localised prostate cancer 2020 · Cochrane Headline outcomes only
  HR 0.63 [0.21, 1.89]
  1 study · 1098 participants
  Moderate

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

The review found no eligible studies for this question.

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 248 participants
  Moderate

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 248 participants
  Moderate

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

The review found no eligible studies for this question.

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

The review found no eligible studies for this question.

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Laparaoscopic radical prostatectomy and robotic‐assisted laparoscopic radical prostatectomy vs open radical prostatectomy

Laparaoscopic radical prostatectomy and robotic‐assisted… showed no clear difference in overall surgical complications (short‐term) compared with open radical prostatectomy (low certainty).

• Laparoscopic and robotic‐assisted versus open radical prostatectomy for the treatment of localised prostate cancer 2017 · Cochrane Headline outcomes only
  RR 0.41 [0.16, 1.04]
  1 study · 308 participants
  Low