Cochrane · systematic review · CD006590
Radical prostatectomy versus deferred treatment for localised prostate cancer
Vernooij, RWM, Lancee, M, Cleves, A, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 42.9%Moderate 8 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Radical prostatectomy compared to watchful waiting for localised prostate cancer
Population: men with localised prostate cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death from any causeMedian Radical prostatectomy vs watchful waiting | HR 0.79 [0.7, 0.9] | 3 studies · 1537 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Time to death from prostate cancerMedian Radical prostatectomy vs watchful waiting | HR 0.57 [0.44, 0.73] | 2 studies · 1426 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Time to disease progressionMedian Radical prostatectomy vs watchful waiting | HR 0.43 [0.35, 0.54] | 2 studies · 1426 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
Time to metastatic diseaseMedian Radical prostatectomy vs watchful waiting | HR 0.56 [0.46, 0.7] | 2 studies · 1426 participants | Moderate Downgraded: risk of bias, inconsistency, indirectness |
Quality of life Radical prostatectomy vs watchful waiting | RR 1 [0.85, 1.16] | 1 study · 339 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
Urinary function: incontinence Radical prostatectomy vs watchful waiting | RR 3.97 [2.34, 6.74] | 1 study · 731 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
Sexual function: erectile dysfunction Radical prostatectomy vs watchful waiting | RR 2.67 [1.63, 4.38] | 1 study · 731 participants | Low Downgraded: risk of bias, inconsistency, indirectness |
Radical prostatectomy compared to active monitoring for localised prostate cancer
Population: localised prostate cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death from any causeMedian Radical prostatectomy vs active monitoring | HR 0.93 [0.65, 1.33] | 1 study · 1098 participants | Moderate Downgraded: risk of bias, imprecision |
Time to death from prostate cancerMedian Radical prostatectomy vs active monitoring | HR 0.63 [0.21, 1.89] | 1 study · 1098 participants | Moderate Downgraded: risk of bias, imprecision |
Time to disease progressionMedian Radical prostatectomy vs active monitoring | HR 0.39 [0.27, 0.56] | 1 study · 1098 participants | Moderate Downgraded: risk of bias, imprecision |
Incidence of metastatic diseaseMedian Radical prostatectomy vs active monitoring | RR 0.39 [0.21, 0.73] | 1 study · 1098 participants | Moderate Downgraded: risk of bias, imprecision |
Health‐related quality of life Radical prostatectomy vs active monitoring | no estimate extracted | 1 study · 856 participants | Moderate Downgraded: risk of bias, imprecision |
Urinary function Radical prostatectomy vs active monitoring | no estimate extracted | 1 study · 782 participants | Low Downgraded: risk of bias, imprecision |
Sexual function Radical prostatectomy vs active monitoring | no estimate extracted | 1 study · 756 participants | Low Downgraded: risk of bias, imprecision |