Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews

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No studies found 3 · 42.9%GRADE not reported 1 · 14.3%Very low 2 · 28.6%Low 1 · 14.3%Moderate 0 · 0%High 0 · 0%

Quinolone vs macrolides

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

Quinolone showed no clear difference in number of participants experiencing one or more exacerbations… compared with macrolide (low certainty).

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
OR 1 [0.32, 3.1]
1 study · 50 participants
Low

Quinolone vs macrolides

All‐cause mortality · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
GRADE not reported

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoroquinolones vs macrolides

Diarrhoea · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes diarrhoea on compared with macrolides (very low certainty).

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
RR 0.6 [0.24, 1.49]
2 studies · 189 participants
Very low

Fluoroquinolones vs macrolides

Relapse ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoroquinolones vs macrolides

Serious adverse events ‐ not reported · patients with Shigella dysentery

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoroquinolones vs macrolides

Other adverse events clinical criteria · patients with Shigella dysentery

It is very uncertain whether fluoroquinolones changes other adverse events clinical criteria compared with macrolides (very low certainty).

1 finding from 1 review

Antibiotic therapy for Shigella dysentery 2010 · Cochrane Headline outcomes only
RR 1.33 [0.32, 5.56]
1 study · 76 participants
Very low