Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 2 reviews · Gut

No studies found 2 · 11.1%GRADE not reported 1 · 5.6%Very low 0 · 0%Low 6 · 33.3%Moderate 9 · 50%High 0 · 0%

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Clinically important upper GI bleeding · people admitted to intensive care units

Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).

1 finding from 1 review