Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Prostanoids vs pentoxifylline

Ulcer healing · people with critical limb ischaemia

It is very uncertain whether prostanoids changes ulcer healing compared with pentoxifylline (very low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 1.61 [1.13, 2.3]
1 study · 70 participants
Very low

Prostanoids vs naftidrofuryl

Ulcer healing · people with critical limb ischaemia

Prostanoids showed no clear difference in ulcer healing compared with naftidrofuryl (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.97 [0.46, 2.03]
2 studies · 39 participants
Low

Prostanoids vs placebo

Ulcer healing · people with critical limb ischaemia

Prostanoids probably leads to higher ulcer healing compared with placebo (moderate certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 1.24 [1.04, 1.48]
11 studies · 1719 participants
Moderate

Prostanoids vs lumbar sympathectomy

Complete ulcer healing without rest pain or major amputation (per protocol) Clinical assessment · people with critical limb ischaemia due to non‐reconstructable peripheral arterial disease

Prostanoids may leads to higher complete ulcer healing without rest pain or major amputation (per… compared with lumbar sympathectomy (low certainty).

1 finding from 1 review

Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non‐reconstructable peripheral arterial… 2018 · Cochrane Headline outcomes only
RR 1.63 [1.3, 2.05]
1 study · 162 participants
Low