What do systematic reviews say?

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 255 participants
  Low
• Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
  RR 1.72 [1.33, 2.22]
  2 studies · 94205 participants
  Moderate

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in numbers of participants with at least 1 clinically significant… compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 1.35 [0.95, 1.9]
  3 studies · 499 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in number of participants with WHO Grade 3 or 4 bleeding up to 30 days… compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 0.99 [0.52, 1.88]
  2 studies · 421 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in time to first bleeding episode (days) compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  HR 1.11 [0.64, 1.91]
  1 study · 255 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 333 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in mortality from all causes up to 30 days from study entry compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 1.78 [0.83, 3.81]
  1 study · 255 participants
  Low