What do systematic reviews say?

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.31 [0.06, 1.49]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics may leads to lower prelabour rupture of membranes compared with placebo (low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.34 [0.15, 0.78]
  1 study · 229 participants
  Low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics showed no clear difference in preterm delivery compared with placebo (high certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.88 [0.72, 1.09]
  6 studies · 3663 participants
  High

Prophylactic antibiotics vs placebo

It is very uncertain whether prophylactic antibiotics changes chorioamnionitis compared with placebo (very low certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.62 [0.1, 3.62]
  1 study · 229 participants
  Very low

Prophylactic antibiotics vs placebo

Prophylactic antibiotics probably leads to lower puerperal sepsis/postpartum endometritis compared with placebo (moderate certainty).

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  RR 0.53 [0.35, 0.82]
  3 studies · 627 participants
  Moderate

Prophylactic antibiotics vs placebo

• Antibiotic prophylaxis during the second and third trimester to reduce adverse pregnancy outcomes and morbidity 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal composite morbidity compared with after neonatal umbilical cord clamping (high certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 0.67 [0.54, 0.82]
  10 studies · 5041 participants
  High

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal endomyometritis compared with after neonatal umbilical cord clamping (high certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 0.54 [0.36, 0.79]
  10 studies · 5041 participants
  High

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… leads to lower maternal wound Infection compared with after neonatal umbilical cord clamping (high certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 0.59 [0.44, 0.81]
  10 studies · 5041 participants
  High

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in maternal UTI/cystitis/pyelonephritis compared with after neonatal umbilical cord clamping (moderate certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 1.02 [0.65, 1.59]
  8 studies · 4001 participants
  Moderate

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in maternal respiratory infection (pneumonia) compared with after neonatal umbilical cord clamping (low certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 2.3 [0.34, 15.45]
  2 studies · 1158 participants
  Low

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in neonatal sepsis compared with after neonatal umbilical cord clamping (moderate certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 0.76 [0.51, 1.13]
  5 studies · 2907 participants
  Moderate

Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping

Prophylactic intravenous antibiotics administered before cesarean… showed no clear difference in neonatal ICU admission compared with after neonatal umbilical cord clamping (high certainty).

• Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing… 2014 · Cochrane Headline outcomes only
  RR 0.91 [0.74, 1.13]
  6 studies · 3708 participants
  High