What do systematic reviews say?

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 158 participants
  Very low

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes withdrawal due to adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  RR 0.64 [0.26, 1.58]
  3 studies · 196 participants
  Very low

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

• Non‐contraceptive oestrogen‐containing preparations for controlling symptoms of premenstrual syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  206 participants
  Very low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Progestogen showed no clear difference in live birth or ongoing pregnancy (Prog + Ant vs Ant) compared with placebo or no pretreatment (low certainty).

• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  OR 0.67 [0.18, 2.54]
  1 study · 47 participants
  Low
• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  OR 1.35 [0.69, 2.65]
  2 studies · 222 participants
  Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Progestogen showed no clear difference in pregnancy loss (Prog + Ag vs Ag) compared with placebo or no pretreatment (low certainty).

• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  OR 2.26 [0.67, 7.55]
  2 studies · 222 participants
  Low
• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  OR 0.36 [0.06, 2.09]
  1 study · 47 participants
  Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

The review found no eligible studies for this question.

• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  OR 1.05 [0.06, 17.76]
  1 study · 47 participants
  Low

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

The review found no eligible studies for this question.

• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found