Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Increased salivary IgA · children aged 6‐12 years

Postbiotics increase salivary IgA (immune modulation) in human trials (ungraded narrative synthesis).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
Daily for 14 days to 4 weeks · Clinical; salivary/plaque sampling
Postbiotic toothpaste significantly increased salivary IgA versus fluoride toothpaste (Basir 2022); the review also cites Lin 2022 for postbiotic immune modulation/IgA; no pooled estimate.
1 study
GRADE not reported

Increased salivary pH · children aged 6‐12 years

Postbiotic toothpaste raises salivary pH in one pediatric RCT (ungraded).

1 finding from 1 review

Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomes
4 weeks · Clinical; salivary/plaque sampling
Postbiotic toothpaste significantly increased salivary pH versus fluoride toothpaste in children (Basir 2022); postbiotics are also proposed to buffer acidic pH; no pooled estimate.
1 study
GRADE not reported