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What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 64 findings · 7 reviews

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No studies found 11 · 17.2%GRADE not reported 5 · 7.8%Very low 29 · 45.3%Low 14 · 21.9%Moderate 2 · 3.1%High 3 · 4.7%

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse effects (central nervous system) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ central nervous system events (e.g. confusion,… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Smoking cessation · young people

It is very uncertain whether pharmacological interventions changes bupropion vs placebo Smoking cessation compared with placebo (very low certainty).

3 findings from 1 review

Pharmacological interventions vs placebo

Adverse events (control ‐ placebo) · young people
3 findings from 1 review