Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 28 findings · 3 reviews

No studies found 4 · 14.3%GRADE not reported 5 · 17.9%Very low 7 · 25%Low 11 · 39.3%Moderate 1 · 3.6%High 0 · 0%

TRIFLUOPERAZINE vs placebo

Global state ‐ clinical improvement ‐ medium term As defined by each study · patients with schizophrenia

TRIFLUOPERAZINE may leads to higher global state ‐ clinical improvement ‐ medium term As defined by each… compared with PLACEBO (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Global state ‐ relapse or worsening ‐ medium term Numbers of participants experiencing relapse/worsening · patients with schizophrenia

TRIFLUOPERAZINE may leads to lower global state ‐ relapse or worsening ‐ medium term Numbers of… compared with PLACEBO (low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Mental state ‐ any clinically significant response in psychotic symptoms (as defined by each study) ‐ medium term Numbers of participants experiencing 'intensified symptoms' · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes mental state ‐ any clinically significant response in psychotic… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes leaving the study early ‐ any reason ‐ medium term Number of… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Severe adverse effects ‐ short term Numbers of participants leaving the studies due to severe adverse effects · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes severe adverse effects ‐ short term Numbers of participants leaving… compared with PLACEBO (very low certainty).

1 finding from 1 review

TRIFLUOPERAZINE vs placebo

Behaviour ‐ any clinically significant agitation or distress ‐ medium term As defined by each study · patients with schizophrenia

It is very uncertain whether TRIFLUOPERAZINE changes behaviour ‐ any clinically significant agitation or distress ‐… compared with PLACEBO (very low certainty).

1 finding from 1 review