Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

67 questions · 69 findings · 9 reviews

No studies found 24 · 34.8%GRADE not reported 7 · 10.1%Very low 27 · 39.1%Low 7 · 10.1%Moderate 4 · 5.8%High 0 · 0%

Pentoxifylline vs Spirulina

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether pentoxifylline changes burning sensation (VAS 0-100) compared with spirulina (very low certainty).

1 finding from 1 review

Pentoxifylline vs multivitamin and mineral supplement

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
    1 study · 29 participants
    GRADE not reported

Pentoxifylline vs Placebo or no active treatment

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline led to lower difficulty in speech (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review

Pentoxifylline vs Placebo or no active treatment

Difficulty in swallowing (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline led to lower difficulty in swallowing (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.

1 finding from 1 review