Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

39 questions · 39 findings · 4 reviews · Headline outcomes only

No studies found 9 · 23.1%GRADE not reported 0 · 0%Very low 3 · 7.7%Low 12 · 30.8%Moderate 5 · 12.8%High 10 · 25.6%

Titrated oxygen therapy vs high‐flow oxygen therapy

Mortality (respiratory‐ related and all‐cause · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy may leads to lower mortality (respiratory‐ related and all‐cause compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Titrated oxygen therapy vs high‐flow oxygen therapy

Ventilation of any type · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy showed no clear difference in ventilation of any type compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Death at 1 year · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) showed no clear difference in death at 1 year compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Complete or substantial improvement of condition · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) may leads to higher complete or substantial improvement of condition compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Visual disturbances · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) leads to higher visual disturbances compared with control without HBOT (high certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Complete resolution or significant improvement of osteoradionecrosis · any person with osteoradionecrosis of the jaw or at risk of osteoradionecrosis of the jaw

Hyperbaric oxygen therapy (HBOT) showed no clear difference in complete resolution or significant improvement of osteoradionecrosis compared with control without HBOT (low certainty).

1 finding from 1 review

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Failure of local tumour control ‐ not reported · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to lower failure of local tumour control (local control) compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review