What do systematic reviews say?

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Very low

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

Oral misoprostol 20 µg hourly titrated showed no clear difference in vaginal birth within 24 hours compared with oral misoprostol 25 µg two‐hourly static (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.97 [0.8, 1.16]
  2 studies · 296 participants
  Low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes caesarean section compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.66 [0.63, 4.32]
  2 studies · 296 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation with FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 3 [0.12, 72.45]
  1 study · 146 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes oxytocin augmentation compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.04 [0.85, 1.27]
  2 studies · 296 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes uterine hyperstimulation without FHR changes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 4 [0.88, 18.2]
  1 study · 146 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.16]
  2 studies · 296 participants
  Very low

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes admission to NICU compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.38 [0.57, 3.31]
  2 studies · 296 participants
  Very low