Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

105 questions · 110 findings · 17 reviews

No studies found 29 · 26.4%GRADE not reported 17 · 15.5%Very low 27 · 24.5%Low 17 · 15.5%Moderate 16 · 14.5%High 4 · 3.6%

Aciclovir (oral or intravenous) for treatment vs placebo

Cost of oral care · Patients being treated for cancer with established oral HSV infection (bone marrow transplant recipients / immunocompromised)

The review found no eligible studies for this question.

1 finding from 1 review

Dextrose gel vs control

Receipt of intravenous treatment for hypoglycaemia (yes/no) · newborn infants with hypoglycaemia

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of intravenous rehydration during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral vs intravenous fluoropyrimidines

Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with palliative intent for inoperable advanced or metastatic colorectal cancer with chemotherapy

Oral may leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (low certainty).

1 finding from 1 review

Oral vs intravenous fluoropyrimidines

Grade ≥ 3 neutropenia/granulocytopenia · Patients treated with curative intent for colorectal cancer with neoadjuvant and/or adjuvant chemotherapy

Oral probably leads to lower grade ≥ 3 neutropenia/granulocytopenia compared with intravenous fluoropyrimidines (moderate certainty).

1 finding from 1 review