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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

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No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Quality of life: Chronic pain · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) probably leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children who had sedation failure after 1 dose of sedative agent · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in proportion of children who had sedation failure after 1 dose of… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

EEG sedative‐induced artefact · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) leads to lower EEG sedative‐induced artefact compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (high certainty).

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) may leads to higher number of children with clinical adverse events (any) compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (low certainty).

1 finding from 1 review