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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

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No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Oral midazolam vs chloral hydrate

Incomplete procedure · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

Oral midazolam probably leads to higher incomplete procedures compared with chloral hydrate (moderate certainty).

1 finding from 1 review

Oral midazolam vs chloral hydrate

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Disinhibition or excitation · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Patient discomfort · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Allergic or anaphylactoid reaction · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Supragingival calculus formation (various calculus indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… showed no clear difference in supragingival calculus formation (various calculus indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.

3 findings from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Gingivitis · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… leads to lower gingivitis (gingival inflammation) measured by Gingival Index of Loe… compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral… (high certainty).

2 findings from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Gingival bleeding (various bleeding indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… led to lower gingival bleeding (various bleeding indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.

2 findings from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Plaque · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… leads to lower dental plaque (various plaque indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral… (high certainty).

2 findings from 1 review

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in conjunction with mechanical oral hygiene procedures vs Placebo/control mouthrinse, or no mouthrinse (mechanical oral hygiene alone); controls pooled (protocol's separate comparisons versus mechanical oral hygiene alone and versus placebo/control merged)

Extrinsic tooth staining (various staining indices) · Children or adults with gingivitis or periodontitis capable of performing normal mechanical oral hygiene procedures (some with medical…

Chlorhexidine mouthrinse (any concentration; 0.05% to 0.2%) used in… led to higher extrinsic tooth staining (various staining indices) compared with placebo/control mouthrinse, or no mouthrinse (mechanical oral…; GRADE not reported.

2 findings from 1 review

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Vaginal birth within 24 hours · women in the third trimester for induction of labour with intact membranes

It is very uncertain whether oral misoprostol one‐ to two‐hourly changes vaginal birth within 24 hours compared with oral misoprostol four‐ to six‐hourly (very low certainty).

1 finding from 1 review

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Caesarean section · women in the third trimester for induction of labour with intact membranes

It is very uncertain whether oral misoprostol one‐ to two‐hourly changes caesarean section compared with oral misoprostol four‐ to six‐hourly (very low certainty).

1 finding from 1 review

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Oxytocin augmentation · women in the third trimester for induction of labour with intact membranes

It is very uncertain whether oral misoprostol one‐ to two‐hourly changes oxytocin augmentation compared with oral misoprostol four‐ to six‐hourly (very low certainty).

1 finding from 1 review

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour with intact membranes

It is very uncertain whether oral misoprostol one‐ to two‐hourly changes uterine hyperstimulation without fetal heart rate changes compared with oral misoprostol four‐ to six‐hourly (very low certainty).

1 finding from 1 review