Oral ciclosporin showed no clear difference in adverse events: severe compared with oral azathioprine (low certainty).
Oral methotrexate showed no clear difference in adverse events: severe compared with oral chloroquine (low certainty).
Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Severe compared with metformin combined with OCP (low certainty).
It is very uncertain whether oral contraceptive pill (OCP) changes adverse events ‐ Severe compared with metformin combined with OCP (very low certainty).
Oral chloroquine showed no clear difference in adverse events: severe compared with placebo (low certainty).
Oral methotrexate showed no clear difference in adverse events: severe compared with placebo (moderate certainty).
Oral hydroxychloroquine showed no clear difference in adverse events: severe compared with placebo (moderate certainty).
Oral dehydroepiandrosterone showed no clear difference in adverse events: severe compared with placebo (moderate certainty).
Oral and sublingual immunotherapy may leads to higher number of children with mild‐to‐severe adverse events compared with no therapy (low certainty).